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Romaco at POWTECH in Nuremberg

7 March 2019

Specialist for solid pharmaceuticals

Romaco will take advantage of the upcoming POWTECH 2019 to demonstrate its expertise when it comes to processing pharmaceutical solids with selected technologies from Kilian and Innojet. On show will be a tablet press for mono-layer and bi-layer mode as well as a laboratory-scale processing machine attached to a hot melt device.

Romaco Kilian KTP 590X single-sided rotary press

Another exhibit from Romaco Kilian will be the KTP 590X, a model in the successful KTP-X series. The KTP 590X is an extremely versatile single-sided rotary press which can be used to manufacture both mono-layer and bi-layer tablet formats. It can be switched between mono-layer and bi-layer mode without any modifications to the compression roller set-up. Bi-layer tablets can be compressed at any time on the version with three compression rollers. The tablet press is equipped for this purpose with two standard fill shoe modules, which distribute the powder uniformly in the die. Thanks to the optimised paddle design, even poorly flowing or sticky powders can be processed efficiently and compressed homogeneously. With its three separate compression stations, the Kilian KTP 590X is equally suited for manufacturing effervescent tablets. The powder is tamped initially to prevent the formation of air pockets and capping. Then it is pre-compressed and finally converted into finished tablets in the main compression unit. The dwell time is significantly longer owing to the use of Kilian 28/41 tooling, meaning harder tablets can be made, even at high operating speeds. All in all, the Romaco Kilian KTP 590X single-sided rotary press boasts a maximum output of up to 510,000 tablets per hour, even in bi-layer mode. Low process temperatures, efficient cleaning and changeover and a mature hygiene concept – the KTP 590X single-sided rotary press, too, conforms to the design principles of Romaco Kilian’s successful KTP series: “Cool, Fast & Clean”.

Romaco Innojet VENTILUS® V 5 processing machine

The laboratory-scale version of the Romaco Innojet VENTILUS® V 5 is used for granulating, drying and coating particle sizes from 10 µm to 2 mm. Due to its special design and enhanced processing efficiency, the VENTILUS® V 5 allows up to 25% shorter batch times. The homogeneous flow conditions inside the cylindrical product container enable extremely gentle intermixing of the batch. The process air is controlled by the ORBITER booster, an ingenious container bottom consisting of overlapping circular plates. Together with the ROTOJET, the central bottom spray nozzle, the ORBITER booster forms an innovative functional unit that meets all the requirements for linear scale-ups. The air flow bed technology ensures accurate control of the product movement and equally precise application of the spray liquids. The resulting formulations can achieve the required release profile with between 10 and 15% less spray liquid.

Romaco Innojet IHD 5 hot melt device

The Romaco exhibit will also include the innovative Innojet IHD 5 hot melt device for pharmaceutical applications. This CIP capable device complies with all GMP requirements for coating and granulation with organic waxes and fats. The fact that there is no evaporation during the hot melt process is a crucial advantage. The processing times are up to 85% shorter as a result. What’s more, since there is no need to heat the air in order to dry the product, energy efficiency is improved. The IHD 5 features a design with all components – including the valve block, dosing unit and melting container – integrated in a compact, block-like housing. This makes it easy to connect the mobile device to the VENTILUS® V 5 whenever this is called for by the formulation. All laboratory equipment in the VENTILUS® V 5 series can simply be fitted with the spray air heater which is essential for hot melt applications. Heating the system to 120°C prevents the coating liquid from cooling down in the feeding channels and clogging the spray nozzle. The pulsation-free application of the pharmaceutical hot melt coating ensures outstanding precision and product quality.

On show at POWTECH in Nuremberg (Germany) from April 9 to 11, 2019 (Nuremberg Exhibition Centre, Hall 3, Stand 3-357).

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